New Paper - A05 Hopfner
04.11.2024
How DNA glycosylases repair base lesions within nucleosomes
The mechanism of repairing base lesions within nucleosomes remains to be elucidated. A collaboration between Hopfner and Zhou lab determined the cryo-EM structure of human 8-oxoguanine-DNA glycosylase 1 (hOGG1) bound to 8-oxoguanine lesion in a nucleosome core particle, thereby providing insights into how DNA glycosylases fulfill their repair functions within nucleosomes.
published in Nature Communications: Structural basis for human OGG1 processing 8-oxodGuo within nucleosome core particles
