TRR 237 Nucleic Acid Immunity
print


Breadcrumb Navigation


Content

Publications

Preprints  2024  |   2023   |   2022   |   2021   |   2020   |   2019   |   2018  


Preprints

2024

Luca D, Lee S, Hirota K, Okabe Y, Uehori J, Izawa K, Lanz AL, Schütte V, Sivri B, Tsukamoto Y, Hauck F, Behrendt R, Roers A, Fujita T, Nishikomori R, Lee-Kirsch MA, Kato HAberrant RNA sensing in regulatory T cells causes systemic autoimmunity. Sci Adv. 2024 Mar;10(9):eadk0820. doi: 10.1126/sciadv.adk0820. Epub 2024 Mar 1. PMID: 38427731.

Mishra H, Schlack-Leigers C, Lim EL, Thieck O, Magg T, Raedler J, Wolf C, Klein C, Ewers H, Lee-Kirsch MA, Meierhofer D, Hauck F, Majer O. Disrupted degradative sorting of TLR7 is associated with human lupus. Sci Immunol. 2024 Feb 23;9(92):eadi9575. doi: 10.1126/sciimmunol.adi9575. Epub 2024 Feb 23. PMID: 38207015.

Rösing S, Ullrich F, Meisterfeld S, Schmidt F, Mlitzko L, Croon M, Nattrass RG, Eberl N, Mahlberg J, Schlee M, Wieland A, Simon P, Hilbig D, Reuner U, Rapp A, Bremser J, Mirtschink P, Drukewitz S, Zillinger T, Beissert S, Paeschke K, Hartmann G, Trifunovic A, Bartok E, Günther CChronic endoplasmic reticulum stress in myotonic dystrophy type 2 promotes autoimmunity via mitochondrial DNA release. Nat Commun. 2024 Feb 20;15(1):1534. doi: 10.1038/s41467-024-45535-1. PMID: 38378748.

Tsukamoto Y, Igarashi M, Kato HTargeting cap1 RNA methyltransferases as an antiviral strategy. Cell Chem Biol. 2024 Jan 18;31(1):86-99. doi: 10.1016/j.chembiol.2023.11.011. Epub 2023 Dec 12. PMID: 38091983.

Manoharan J, Rana R, Kuenze G, Gupta D, Elwakiel A, Ambreen S, Wang H, Banerjee K, Zimmermann S, Singh K, Gupta A, Fatima S, Kretschmer S, Schaefer L, Zeng-Brouwers J, Schwab C, Al-Dabet MM, Gadi I, Altmann H, Koch T, Poitz DM, Baber R, Kohli S, Shahzad K, Geffers R, Lee-Kirsch MA, Kalinke U, Meiler J, Mackman N, Isermann B. Tissue factor binds to and inhibits interferon-alpha receptor 1 signaling. Immunity. 2024 Jan 9;57(1):68-85.e11. doi: 10.1016/j.immuni.2023.11.017. Epub 2023 Dec 22. PMID: 38141610.

Heuser-Loy C, Baumgart AK, Hackstein CP, Courrèges CJF, Philipp MS, Thaiss CA, Holland T, Evaristo C, Garbi N, Kurts CConditional NKT Cell Depletion in Mice Reveals a Negative Feedback Loop That Regulates CTL Cross-Priming. J Immunol. 2024 Jan 1;212(1):35-42. doi: 10.4049/jimmunol.2300662. PMID: 38019126.

Nickenig M, Mangan MSJ, Lee HE, Symeonidis K, Henne A, Kaiser R, Geißmar E, Garritsen H, Abdullah Z, Hiller K, Latz E, Lauterbach MA. Cutting Edge: STING Induces ACLY Activation and Metabolic Adaptations in Human Macrophages through TBK1. J Immunol. 2024 Jan 1;212(1):7-11. doi: 10.4049/jimmunol.2200835. PMID: 38038390.

Wolf C, Lim EL, Mokhtari M, Kind B, Odainic A, Lara-Villacanas E, Koss S, Mages S, Menzel K, Engel K, Dückers G, Bernbeck B, Schneider DT, Siepermann K, Niehues T, Goetzke CC, Durek P, Minden K, Dörner T, Stittrich A, Szelinski F, Guerra GM, Massoud M, Bieringer M, de Oliveira Mann CC, Beltrán E, Kallinich T, Mashreghi MF, Schmidt SV, Latz E, Klughammer J, Majer O, Lee-Kirsch MAUNC93B1 variants underlie TLR7-dependent autoimmunity. Sci Immunol. 2024 Jan 11:eadi9769. doi: 10.1126/sciimmunol.adi9769. Online ahead of print. PMID: 38207055.

Valeri E, Unali G, Piras F, Abou-Alezz M, Pais G, Benedicenti F, Lidonnici MR, Cuccovillo I, Castiglioni I, Arévalo S, Spinozzi G, Merelli I, Behrendt R, Oo A, Kim B, Landau NR, Ferrari G, Montini E, Kajaste-Rudnitski A. Removal of innate immune barriers allows efficient transduction of quiescent human hematopoietic stem cells. Mol Ther. 2024 Jan 3;32(1):124-139. doi: 10.1016/j.ymthe.2023.11.020. Epub 2023 Nov 20. PMID: 37990494.

top

2023

Denolly S, Stukalov A, Barayeu U, Rosinski AN, Kritsiligkou P, Joecks S, Dick TP, Pichlmair A, Bartenschlager R. Zika virus remodelled ER membranes contain proviral factors involved in redox and methylation pathways. Nat Commun. 2023 Dec 5;14(1):8045. doi: 10.1038/s41467-023-43665-6. PMID: 38052817.

Gnirck AC, Philipp MS, Waterhölter A, Wunderlich M, Shaikh N, Adamiak V, Henneken L, Kautz T, Xiong T, Klaus D, Tomczyk P, Al-Bahra MM, Menche D, Walkenhorst M, Lantz O, Willing A, Friese MA, Huber TB, Krebs CF, Panzer U, Kurts C, Turner JE. Mucosal-associated invariant T cells contribute to suppression of inflammatory myeloid cells in immune-mediated kidney disease. Nat Commun. 2023 Nov 15;14(1):7372. doi: 10.1038/s41467-023-43269-0.
PMID: 37968302.

Schmidt N, Ganskih S, Wei Y, Gabel A, Zielinski S, Keshishian H, Lareau CA, Zimmermann L, Makroczyova J, Pearce C, Krey K, Hennig T, Stegmaier S, Moyon L, Horlacher M, Werner S, Aydin J, Olguin-Nava M, Potabattula R, Kibe A, Dölken L, Smyth RP, Caliskan N, Marsico A, Krempl C, Bodem J, Pichlmair A, Carr SA, Chlanda P, Erhard F, Munschauer M. SND1 binds SARS-CoV-2 negative-sense RNA and promotes viral RNA synthesis through NSP9.
Cell. 2023 Oct 26;186(22):4834-4850.e23. doi: 10.1016/j.cell.2023.09.002. Epub 2023 Oct 3. PMID: 37794589.

Andersen LL, Huang Y, Urban C, Oubraham L, Winheim E, Stafford C, Nagl D, O'Duill F, Ebert T, Engleitner T, Paludan SR, Krug A, Rad R, Hornung V, Pichlmair A. Systematic P2Y receptor survey identifies P2Y11 as modulator of immune responses and virus replication in macrophages. EMBO J. 2023 Oct 26:e113279. doi: 10.15252/embj.2022113279. Online ahead of print. PMID: 37881155.

Kapp FG, Kretschmer S, Beckmann CCA, Wäsch L, Molitor A, Carapito R, Schubert M, Lucas N, Conrad S, Poignant S, Isidor B, Rohlfs M, Kisaarslan AP, Schanze D, Zenker M, Schmitt-Graeff A, Strahm B, Peters A, Yoshimi A, Driever W, Zillinger T, Günther C, Maharana S, Guan K, Klein C, Ehl S, Niemeyer CM, Unal E, Bahram S, Hauck F, Lee-Kirsch MA, Speckmann C. C-terminal variants in CDC42 drive type I interferon-dependent autoinflammation in NOCARH syndrome reversible by ruxolitinib. Clin Immunol. 2023 Nov;256:109777. doi: 10.1016/j.clim.2023.109777. Epub 2023 Sep 22. PMID: 37741518.

Günther C, Wolf C, Fennen L, Rösing S, Beissert S, Aringer M, Lee-Kirsch MACase Report: Response of cutaneous lupus lesions in SLE to interferon receptor blockade parallels reduction of interferon score in blood
Front Immunol. 2023 Sep 21;14:1253279. doi: 10.3389/fimmu.2023.1253279. eCollection 2023. PMID: 37809086.

Wartewig T, Daniels J, Schulz M, Hameister E, Joshi A, Park J, Morrish E, Venkatasubramani AV, Cernilogar FM, van Heijster FHA, Hundshammer C, Schneider H, Konstantinidis F, Gabler JV, Klement C, Kurniawan H, Law C, Lee Y, Choi S, Guitart J, Forne I, Giustinani J, Müschen M, Jain S, Weinstock DM, Rad R, Ortonne N, Schilling F, Schotta G, Imhof A, Brenner D, Choi J, Ruland JPD-1 instructs a tumor-suppressive metabolic program that restricts glycolysis and restrains AP-1 activity in T cell lymphoma. Nat Cancer. 2023 Oct;4(10):1508-1525. doi: 10.1038/s43018-023-00635-7. Epub 2023 Sep 18. PMID: 37723306.

De Silva NS, Siewiera J, Alkhoury C, Nader GPF, Nadalin F, de Azevedo K, Couty M, Izquierdo HM, Bhargava A, Conrad C, Maurin M, Antoniadou K, Fouillade C, Londono-Vallejo A, Behrendt R, Bertotti K, Serdjebi C, Lanthiez F, Gallwitz L, Saftig P, Herrero-Fernández B, Saez A, González-Granado JM, van Niel G, Boissonnas A, Piel M, Manel N. Nuclear envelope disruption triggers hallmarks of aging in lung alveolar macrophages. Nat Aging. 2023 Oct;3(10):1251-1268. doi: 10.1038/s43587-023-00488-w. Epub 2023 Sep 18. PMID: 37723209.

Govande AA, Babnis AW, Urban C, Habjan M, Hartmann R, Kranzusch PJ, Pichlmair ARNase L-activating 2'-5' oligoadenylates bind ABCF1, ABCF3 and Decr-1. J Gen Virol. 2023 Sep;104(9). doi: 10.1099/jgv.0.001890. PMID: 37676257.

Yin J, Mei Q, Prinz M, Abdullah Z, Panzer U, Li J, von Vietinghoff S, Kurts CFate mapping reveals compartment-specific clonal expansion of mononuclear phagocytes during kidney disease. Kidney Int. 2023 Sep;104(3):605-610. doi: 10.1016/j.kint.2023.04.031. Epub 2023 Jun 7. PMID: 37290602.

Dressel N, Natusch L, Munz CM, Costas Ramon S, Morcos MNF, Loff A, Hiller B, Haase C, Schulze L, Müller P, Lesche M, Dahl A, Luksch H, Rösen-Wolff A, Roers A, Behrendt R, Gerbaulet A. Activation of the cGAS/STING Axis in Genome-Damaged Hematopoietic Cells Does Not Impact Blood Cell Formation or Leukemogenesis. Cancer Res. 2023 Sep 1;83(17):2858-2872. doi: 10.1158/0008-5472.CAN-22-3860. PMID: 37335136.

Andryka-Cegielski K, Soler S, Bartok EUnexpected bonds: Ubiquitin-like conjugation of cGAS/CD-NTases supports their enzymatic activity and antiphage defense. Signal Transduct Target Ther. 2023 Aug 25;8(1):308. doi: 10.1038/s41392-023-01549-7. PMID: 37620346.

Wolf C, Fischer H, Kühl JS, Koss S, Jamra RA, Starke S, Schultz J, Ehl S, Neumann K, Schuetz C, Huber R, Hornung V, Lee-Kirsch MA. Hemophagocytic lymphohistiocytosis–like hyperinflammation due to a de novo mutation in DPP9. J of Allergy Clin Immunol. 2023 Aug 5:S0091-6749(23)00978-8. doi: 10.1016/j.jaci.2023.07.013. PMID: 37544411.

Mohamed AA, Soler S, Wegner J, Bartok E, Stankovic S, Brooks AG, Schlee MInfluenza A Infection Stimulates RIG-I and Enhances Effector Function of Primary Human NK Cells. Int J Mol Sci. 2023 Jul 30;24(15):12220. doi: 10.3390/ijms241512220. PMID: 37569596.

Kira A, Tatsutomi I, Saito K, Murata M, Hattori I, Kajita H, Muraki N, Oda Y, Satoh S, Tsukamoto Y, Kimura S, Onoue K, Yonemura S, Arakawa S, Kato H, Hirashima T, Kawane K. Apoptotic extracellular vesicle formation via local phosphatidylserine exposure drives efficient cell extrusion. Dev Cell. 2023 Jul 24;58(14):1282-1298.e7. doi: 10.1016/j.devcel.2023.05.008. Epub 2023 Jun 13. PMID: 37315563.

Hufbauer M, Rattay S, Hagen C, Quaas A, Pfister H, Hartmann G, Coch C, Akgül B. Poly(I:C) Treatment Prevents Skin Tumor Formation in the Preclinical HPV8 Transgenic Mouse Model. J Invest Dermatol. 2023 Jul;143(7):1197-1207.e3. doi: 10.1016/j.jid.2022.12.007. Epub 2022 Dec 27. PMID: 36584911.

Hackstein CP, Spitzer J, Symeonidis K, Horvatic H, Bedke T, Steglich B, Klein S, Assmus LM, Odainic A, Szlapa J, Kessler N, Beyer M, Schmithausen R, Latz E, Flavell RA, Garbi N, Kurts C, Kümmerer BM, Trebicka J, Roers A, Huber S, Schmidt SV, Knolle PA, Abdullah ZInterferon-induced IL-10 drives systemic T-cell dysfunction during chronic liver injury. J Hepatol. 2023 Jul;79(1):150-166. doi: 10.1016/j.jhep.2023.02.026. Epub 2023 Mar 2.
PMID: 36870611.

Günther CRapid response of cutaneous lupus erythematosus to treatment with the type 1 interferon receptor antagonist anifrolumab. Br J Dermatol. 2023 Jul 17;189(2):151-153. doi: 10.1093/bjd/ljad111. PMID: 37002783.

Körholz J, Gabrielyan A, Sczakiel HL, Schulze L, Rejzek M, Laass MW, Leuchten N, Tiebel O, Aust D, Conrad K, Röber N, Jacobsen EM, Ehmke N, Berner R, Lucas N, Lee-Kirsch MA, Wiedemuth R, Roesler J, Roers A, Amendt T, Schuetz C. Novel mutation and expanding phenotype in IRF2BP2 deficiency. Rheumatology (Oxford). 2023 Apr 3;62(4):1699-1705. doi: 10.1093/rheumatology/keac575. PMID: 36193988.

Günther C, Wenzel J. Lupus erythematosus. J Dtsch Dermatol Ges. 2023 Apr;21(4):426-430. doi: 10.1111/ddg.15049. PMID: 37070503.

Im JH, Duic I, Yoshimura SH, Onomoto K, Yoneyama M, Kato H, Fujita T. Mechanisms of length-dependent recognition of viral double-stranded RNA by RIG-I. Sci Rep. 2023 Apr 18;13(1):6318. doi: 10.1038/s41598-023-33208-w. PMID: 37072508.

Stegelmann F, Teichmann LL, Heidel FH, Crodel CC, Ernst T, Kreil S, Reiter A, Otten S, Schauer S, Körber RM, Kricheldorf K, Isfort S, Döhner H, Brümmendorf TH, Griesshammer M, Döhner K, Koschmieder S. Clinicohematologic and molecular response of essential thrombocythemia patients treated with pegylated interferon-α: a multi-center study of the German Study Group-Myeloproliferative Neoplasms (GSG-MPN).  Leukemia. 2023 Apr;37(4):924-928. doi: 10.1038/s41375-023-01837-9. Epub 2023 Feb 24. PMID: 36828867.

Próchnicki T, Vasconcelos MB, Robinson KS, Mangan MSJ, De Graaf D, Shkarina K, Lovotti M, Standke L, Kaiser R, Stahl R, Duthie FG, Rothe M, Antonova K, Jenster LM, Lau ZH, Rösing S, Mirza N, Gottschild C, Wachten D, Günther C, Kufer TA, Schmidt FI, Zhong FL, Latz E. Mitochondrial damage activates the NLRP10 inflammasome. Nat Immunol. 2023 Apr;24(4):595-603. doi: 10.1038/s41590-023-01451-y. Epub 2023 Mar 20. PMID: 36941400.

Vornholz L, Isay SE, Kurgyis Z, Strobl DC, Loll P, Mosa MH, Luecken MD, Sterr M, Lickert H, Winter C, Greten FR, Farin HF, Theis FJ, Ruland JSynthetic enforcement of STING signaling in cancer cells appropriates the immune microenvironment for checkpoint inhibitor therapy. Sci Adv. 2023 Mar 17;9(11):eadd8564. doi: 10.1126/sciadv.add8564. Epub 2023 Mar 15. PMID: 36921054.

Wegner J, Hunkler C, Ciupka K, Hartmann G, Schlee MIncreased IKKϵ protein stability ensures efficient type I interferon responses in conditions of TBK1 deficiency. Front Immunol. 2023 Mar 3;14:1073608. doi: 10.3389/fimmu.2023.1073608. eCollection 2023. PMID: 36936901.

Winheim E, Eser T, Deák F, Ahmed MIM, Baranov O, Rinke L, Eisenächer K, Santos-Peral A, Karimzadeh H, Pritsch M, Scherer C, Muenchhoff M, Hellmuth JC, von Bergwelt-Baildon M, Olbrich L, Hoelscher M, Wieser A, Kroidl I, Rothenfusser S, Geldmacher C, Krug ABDistinct and dynamic activation profiles of circulating dendritic cells and monocytes in mild COVID-19 and after yellow fever vaccination. Eur J Immunol. 2023 Mar;53(3):e2250090. doi: 10.1002/eji.202250090. Epub 2022 Dec 9. PMID: 36404054.

Koerber RM, Schneider RK, Pritchard JE, Teichmann LL, Schumacher U, Brossart P, Gütgemann I. Nestin expression in osteocytes following myeloablation and during bone marrow metastasis. Br J Haematol. 2023 Mar;200(5):643-651. doi: 10.1111/bjh.18563. Epub 2022 Nov 15. PMID: 36382360

Schulz MS, Sartorius von Bach CB, Marinkovic E, Günther C, Behrendt R, Roers ADevelopment of an RNase H2 Activity Assay for Clinical Screening. J Clin Med. 2023 Feb 17;12(4):1598. doi: 10.3390/jcm12041598. PMID: 36836134.

Morrish E, Wartewig T, Kratzert A, Rosenbaum M, Steiger K, Ruland JThe fusion oncogene VAV1-MYO1F triggers aberrant T-cell receptor signaling in vivo and drives peripheral T-cell lymphoma in mice. Eur J Immunol. 2023 Mar;53(3):e2250147. doi: 10.1002/eji.202250147. Epub 2023 Feb 15. PMID: 36541400.

Tsukamoto Y, Hiono T, Yamada S, Matsuno K, Faist A, Claff T, Hou J, Namasivayam V, Vom Hemdt A, Sugimoto S, Ng JY, Christensen MH, Tesfamariam YM, Wolter S, Juranek S, Zillinger T, Bauer S, Hirokawa T, Schmidt FI, Kochs G, Shimojima M, Huang YS, Pichlmair A, Kümmerer BM, Sakoda Y, Schlee M, Brunotte L, Müller CE, Igarashi M, Kato HInhibition of cellular RNA methyltransferase abrogates influenza virus capping and replication. Science. 2023 Feb 10;379(6632):586-591. doi: 10.1126/science.add0875. Epub 2023 Feb 9. PMID: 36758070.

2022

Wolf C, Lee-Kirsch MAKeeping immunostimulatory self-RNA under the rADAR. Nat Rev Rheumatol. 2022 Dec;18(12):681-682. doi: 10.1038/s41584-022-00859-4. PMID: 36203062.

Russ A, Wittmann S, Tsukamoto Y, Herrmann A, Deutschmann J, Lagisquet J, Ensser A, Kato H, Gramberg T. Nsp16 shields SARS-CoV-2 from efficient MDA5 sensing and IFIT1-mediated restriction. EMBO Rep. 2022 Dec 6;23(12):e55648. doi: 10.15252/embr.202255648. Epub 2022 Oct 26. PMID: 36285486.

Wuebben C, Bartok E, Hartmann GInnate sensing of mRNA vaccines. Curr Opin Immunol. 2022 Dec;79:102249. doi: 10.1016/j.coi.2022.102249. Epub 2022 Oct 27. PMID: 36334350.

Becker-Gotot J, Meissner M, Kotov V, Jurado-Mestre B, Maione A, Pannek A, Albert T, Flores C, Schildberg FA, Gleeson PA, Reipert BM, Oldenburg J, Kurts CImmune tolerance against infused FVIII in hemophilia A is mediated by PD-L1+ Tregs. J Clin Invest. 2022 Nov 15;132(22):e159925. doi: 10.1172/JCI159925. PMID: 36107620.

Mangan MSJ, Gorki F, Krause K, Heinz A, Pankow A, Ebert T, Jahn D, Hiller K, Hornung V, Maurer M, Schmidt FI, Gerhard R, Latz ETranscriptional licensing is required for Pyrin inflammasome activation in human macrophages and bypassed by mutations causing familial Mediterranean fever. PLoS Biol. 2022 Nov 7;20(11):e3001351. doi: 10.1371/journal.pbio.3001351. eCollection 2022 Nov. PMID: 36342970.

Szego EM, Malz L, Bernhardt N, Rösen-Wolff A, Falkenburger BH, Luksch H. Constitutively active STING causes neuroinflammation and degeneration of dopaminergic neurons in mice. Elife. 2022 Oct 31;11:e81943. doi: 10.7554/eLife.81943. PMID: 36314770.

Blau K, Lehr S, Aschoff R, Al Gburi S, Brück N, Chapsa M, Schnabel A, Abraham S, Jöhrens K, Beissert S, Günther C. Course and outcome of chilblain-like acral lesions during COVID-19 pandemic. J Eur Acad Dermatol Venereol. 2023 Jan;37(1):e29-e31. doi: 10.1111/jdv.18582. Epub 2022 Oct 1. PMID: 36149533.

Lutz MB, Ali S, Audiger C, Autenrieth SE, Berod L, Bigley V, Cyran L, Dalod M, Dörrie J, Dudziak D, Flórez-Grau G, Giusiano L, Godoy GJ, Heuer M, Krug AB, Lehmann CHK, Mayer CT, Naik SH, Scheu S, Schreibelt G, Segura E, Seré K, Sparwasser T, Tel J, Xu H, Zenke M. Guidelines for mouse and human DC generation. Eur J Immunol. 2022 Oct 27. doi: 10.1002/eji.202249816. Online ahead of print. PMID: 36303448.

Maharana S, Kretschmer S, Hunger S, Yan X, Kuster D, Traikov S, Zillinger T, Gentzel M, Elangovan S, Dasgupta P, Chappidi N, Lucas N, Maser KI, Maatz H, Rapp A, Marchand V, Chang YT, Motorin Y, Hubner N, Hartmann G, Hyman AA, Alberti S, Lee-Kirsch MASAMHD1 controls innate immunity by regulating condensation of immunogenic self RNA. Mol Cell. 2022 Oct 6;82(19):3712-3728.e10. doi: 10.1016/j.molcel.2022.08.031. Epub 2022 Sep 22. PMID: 36150385.

Nicolai M, Steinberg J, Obermann HL, Solis FV, Bartok E, Bauer S, Jung S. Identification of an Optimal TLR8 Ligand by Alternating the Position of 2'-O-Ribose Methylation. Int J Mol Sci. 2022 Sep 22;23(19):11139. doi: 10.3390/ijms231911139. PMID: 36232437.

Hänchen V, Kretschmer S, Wolf C, Engel K, Khattak S, Neumann K, Lee-Kirsch MAGeneration of induced pluripotent stem cell lines from three patients with Aicardi-Goutières syndrome type 5 due to biallelic SAMDH1 mutations. Stem Cell Res. 2022 Oct;64:102912. doi: 10.1016/j.scr.2022.102912. Epub 2022 Sep 9. PMID: 36115319.

Akbal A, Dernst A, Lovotti M, Mangan MSJ, McManus RM, Latz EHow location and cellular signaling combine to activate the NLRP3 inflammasome. Cell Mol Immunol. 2022 Nov;19(11):1201-1214. doi: 10.1038/s41423-022-00922-w. Epub 2022 Sep 20. PMID: 36127465.

Lee S, Hirota K, Schuette V, Fujita T, Kato H. Attenuation of regulatory T cell function by type I IFN signaling in an MDA5 gain-of-function mutant mouse model. Biochem Biophys Res Commun. 2022 Nov 12;629:171-175. doi: 10.1016/j.bbrc.2022.09.017. Epub 2022 Sep 7. PMID: 36122455.

Stazzoni S, Böhmer DFR, Hernichel F, Özdemir D, Pappa A, Drexler D, Bauernfried S, Witte G, Wagner M, Veth S, Hopfner KP, Hornung V, König LM, Carell TNovel Poxin Stable cGAMP-Derivatives Are Remarkable STING Agonists. Angew Chem Int Ed Engl. 2022 Oct 4;61(40):e202207175. doi: 10.1002/anie.202207175. Epub 2022 Aug 31. PMID: 35876840.

Schwab LSU, Londrigan SL, Brooks AG, Hurt AC, Sahu A, Deng YM, Moselen J, Coch C, Zillinger T, Hartmann G, Reading PC. Induction of Interferon-Stimulated Genes Correlates with Reduced Growth of Influenza A Virus in Lungs after RIG-I Agonist Treatment of Ferrets. J Virol. 2022 Aug 24;96(16):e0055922. doi: 10.1128/jvi.00559-22. Epub 2022 Aug 2. PMID: 35916513.

Kessler N, Viehmann SF, Krollmann C, Mai K, Kirschner KM, Luksch H, Kotagiri P, Böhner AMC, Huugen D, de Oliveira Mann CC, Otten S, Weiss SAI, Zillinger T, Dobrikova K, Jenne DE, Behrendt R, Ablasser A, Bartok E, Hartmann G, Hopfner KP, Lyons PA, Boor P, Rösen-Wolff A, Teichmann LL, Heeringa P, Kurts C, Garbi NMonocyte-derived macrophages aggravate pulmonary vasculitis via cGAS/STING/IFN-mediated nucleic acid sensing. J Exp Med. 2022 Oct 3;219(10):e20220759. doi: 10.1084/jem.20220759. Epub 2022 Aug 23. PMID: 35997679.

Lutz K, Musumeci A, Sie C, Dursun E, Winheim E, Bagnoli J, Ziegenhain C, Rausch L, Bergen V, Luecken MD, Oostendorp RAJ, Schraml BU, Theis FJ, Enard W, Korn T, Krug AB. Ly6D+Siglec-H+ precursors contribute to conventional dendritic cells via a Zbtb46+Ly6D+ intermediary stage. Nat Commun. 2022 Jun 16;13(1):3456. doi: 10.1038/s41467-022-31054-4. PMID: 35705536; PMCID: PMC9200809.

Bertheloot D, Wanderley CW, Schneider AH, Schiffelers LD, Wuerth JD, Tödtmann JM, Maasewerd S, Hawwari I, Duthie F, Rohland C, Ribeiro LS, Jenster LM, Rosero N, Tesfamariam YM, Cunha FQ, Schmidt FI, Franklin BS. Nanobodies dismantle post-pyroptotic ASC specks and counteract inflammation in vivo. EMBO Mol Med. 2022 Jun 8;14(6):e15415. doi: 10.15252/emmm.202115415. Epub 2022 Apr 19. PMID: 35438238; PMCID: PMC9174887.

Jocher G, Grass V, Tschirner SK, Riepler L, Breimann S, Kaya T, Oelsner M, Hamad MS, Hofmann LI, Blobel CP, Schmidt-Weber CB, Gokce O, Jakwerth CA, Trimpert J, Kimpel J, Pichlmair A, Lichtenthaler SF. ADAM10 and ADAM17 promote SARS-CoV-2 cell entry and spike protein-mediated lung cell fusion. EMBO Rep. 2022 Jun 7;23(6):e54305. doi: 10.15252/embr.202154305. Epub 2022 May 8. PMID: 35527514; PMCID: PMC9171409.

Pietzsch L, Körholz J, Boschann F, Sergon M, Dorjbal B, Yee D, Gilly V, Kämmerer E, Paul D, Kastl C, Laass MW, Berner R, Jacobsen EM, Roesler J, Aust D, Lee-Kirsch MA, Snow AL, Schuetz C. Hyper-IgE and Carcinoma in CADINS Disease. Front Immunol. 2022 May 16;13:878989. doi: 10.3389/fimmu.2022.878989. PMID: 35651609; PMCID: PMC9149281.

Schubert N, Schumann T, Daum E, Flade K, Ge Y, Hagedorn L, Edelmann W, Müller L, Schmitz M, Kuut G, Hornung V, Behrendt R, Roers A. Genome Replication Is Associated With Release of Immunogenic DNA Waste. Front Immunol. 2022 May 11;13:880413. doi: 10.3389/fimmu.2022.880413. PMID: 35634291; PMCID: PMC9130835.

Hollenhorst MI, Nandigama R, Evers SB, Gamayun I, Abdel Wadood N, Salah A, Pieper M, Wyatt A, Stukalov A, Gebhardt A, Nadolni W, Burow W, Herr C, Beisswenger C, Kusumakshi S, Ectors F, Kichko TI, Hübner L, Reeh P, Munder A, Wienhold SM, Witzenrath M, Bals R, Flockerzi V, Gudermann T, Bischoff M, Lipp P, Zierler S, Chubanov V, Pichlmair A, König P, Boehm U, Krasteva-Christ G. Bitter taste signaling in tracheal epithelial brush cells elicits innate immune responses to bacterial infection. J Clin Invest. 2022 May 3:e150951. doi: 10.1172/JCI150951. Epub ahead of print. PMID: 35503420.

Cetin Gedik K, Lamot L, Romano M, Demirkaya E, Piskin D, Torreggiani S, Adang LA, Armangue T, Barchus K, Cordova DR, Crow YJ, Dale RC, Durrant KL, Eleftheriou D, Fazzi EM, Gattorno M, Gavazzi F, Hanson EP, Lee-Kirsch MA, Montealegre Sanchez GA, Neven B, Orcesi S, Ozen S, Poli MC, Schumacher E, Tonduti D, Uss K, Aletaha D, Feldman BM, Vanderver A, Brogan PA, Goldbach-Mansky R. The 2021 European Alliance of Associations for Rheumatology/American College of Rheumatology Points to Consider for Diagnosis and Management of Autoinflammatory Type I Interferonopathies: CANDLE/PRAAS, SAVI, and AGS. Arthritis Rheumatol. 2022 May;74(5):735-751. doi: 10.1002/art.42087. Epub 2022 Mar 21. PMID: 35315249.

Cetin Gedik K, Lamot L, Romano M, Demirkaya E, Piskin D, Torreggiani S, Adang LA, Armangue T, Barchus K, Cordova DR, Crow YJ, Dale RC, Durrant KL, Eleftheriou D, Fazzi EM, Gattorno M, Gavazzi F, Hanson EP, Lee-Kirsch MA, Montealegre Sanchez GA, Neven B, Orcesi S, Ozen S, Poli MC, Schumacher E, Tonduti D, Uss K, Aletaha D, Feldman BM, Vanderver A, Brogan PA, Goldbach-Mansky R. The 2021 European Alliance of Associations for Rheumatology/American College of Rheumatology points to consider for diagnosis and management of autoinflammatory type I interferonopathies: CANDLE/PRAAS, SAVI and AGS. Ann Rheum Dis. 2022 May;81(5):601-613. doi: 10.1136/annrheumdis-2021-221814. Epub 2022 Jan 27. PMID: 35086813; PMCID: PMC9036471.

Groll T, Silva M, Sarker RSJ, Tschurtschenthaler M, Schnalzger T, Mogler C, Denk D, Schölch S, Schraml BU, Ruland J, Rad R, Saur D, Weichert W, Jesinghaus M, Matiasek K, Steiger K. Comparative Study of the Role of Interepithelial Mucosal Mast Cells in the Context of Intestinal Adenoma-Carcinoma Progression. Cancers (Basel). 2022 Apr 30;14(9):2248. doi: 10.3390/cancers14092248. PMID: 35565377; PMCID: PMC9105816.

Steiner A, Hrovat-Schaale K, Prigione I, Yu CH, Laohamonthonkul P, Harapas CR, Low RRJ, De Nardo D, Dagley LF, Mlodzianoski MJ, Rogers KL, Zillinger T, Hartmann G, Gantier MP, Gattorno M, Geyer M, Volpi S, Davidson S, Masters SL. Deficiency in coatomer complex I causes aberrant activation of STING signalling. Nat Commun. 2022 Apr 28;13(1):2321. doi: 10.1038/s41467-022-29946-6. PMID: 35484149; PMCID: PMC9051092.

Serrero MC, Girault V, Weigang S, Greco TM, Ramos-Nascimento A, Anderson F, Piras A, Hickford Martinez A, Hertzog J, Binz A, Pohlmann A, Prank U, Rehwinkel J, Bauerfeind R, Cristea IM, Pichlmair A, Kochs G, Sodeik B. The interferon-inducible GTPase MxB promotes capsid disassembly and genome release of herpesviruses. Elife. 2022 Apr 27;11:e76804. doi: 10.7554/eLife.76804. PMID: 35475759; PMCID: PMC9150894.

Veth S, Fuchs A, Özdemir D, Dialer C, Drexler DJ, Knechtel F, Witte G, Hopfner KP, Carell T, Ploetz E. Chemical Synthesis of the Fluorescent, Cyclic Dinucleotides cth GAMP. Chembiochem. 2022 Apr 20;23(8):e202200005. doi: 10.1002/cbic.202200005. Epub 2022 Mar 10. PMID: 35189023.

Krollmann C, Cieslak K, Koerber RM, Luksch H, Rösen-Wolff A, Brossart P, Teichmann LL. Quantification of unperturbed phosphoprotein levels in immune cell subsets with phosphoflow to assess immune signaling in autoimmune disease. STAR Protoc. 2022 Apr 13;3(2):101309. doi: 10.1016/j.xpro.2022.101309. PMID: 35496781; PMCID: PMC9038771.

Köllisch G, Solis FV, Obermann HL, Eckert J, Müller T, Vierbuchen T, Rickmeyer T, Muche S, Przyborski JM, Heine H, Kaufmann A, Baumeister S, Lingelbach K, Bauer S. TLR8 is activated by 5'-methylthioinosine, a Plasmodium falciparum-derived intermediate of the purine salvage pathway. Cell Rep. 2022 Apr 12;39(2):110691. doi: 10.1016/j.celrep.2022.110691. PMID: 35417716.

Broser P, von Mengershausen U, Heldt K, Bartholdi D, Braun D, Wolf C, Lee-Kirsch MA. Precision treatment of Singleton Merten syndrome with ruxolitinib: a case report. Pediatr Rheumatol Online J. 2022 Apr 11;20(1):24. doi: 10.1186/s12969-022-00686-7. PMID: 35410415; PMCID: PMC8995680.

Fischer K, Aringer M, Steininger J, Heil J, Beissert S, Abraham S, Günther C. Improvement of cutaneous inflammation and panniculitis in patients with dermatomyositis by the Janus kinase inhibitor baricitinib. Br J Dermatol. 2022 Mar 23. doi: 10.1111/bjd.21252. Epub ahead of print. PMID: 35318646.

Kerle IA, Jägerhuber L, Secci R, Pfarr N, Blüm P, Roesch R, Götze KS, Weichert W, Bassermann F, Ruland J, Winter C. Circulating Tumor DNA Profiling of a Diffuse Large B Cell Lymphoma Patient with Secondary Acute Myeloid Leukemia. Cancers (Basel). 2022 Mar 8;14(6):1371. doi: 10.3390/cancers14061371. PMID: 35326522; PMCID: PMC8946858.

Marx S, Kümmerer BM, Grützner C, Kato H, Schlee M, Renn M, Bartok E, Hartmann G. RIG-I-induced innate antiviral immunity protects mice from lethal SARS-CoV-2 infection. Mol Ther Nucleic Acids. 2022 Mar 8;27:1225-1234. doi: 10.1016/j.omtn.2022.02.008. Epub 2022 Feb 13. PMID: 35186439; PMCID: PMC8841011.

Berndt N, Wolf C, Fischer K, Cura Costa E, Knuschke P, Zimmermann N, Schmidt F, Merkel M, Chara O, Lee-Kirsch MA, Günther C. Photosensitivity and cGAS-Dependent IFN-1 Activation in Patients with Lupus and TREX1 Deficiency. J Invest Dermatol. 2022 Mar;142(3 Pt A):633-640.e6. doi: 10.1016/j.jid.2021.04.037. Epub 2021 Aug 14. PMID: 34400195.

Haebe S, Keay W, Alig S, Mohr AW, Martin LK, Heide M, Secci R, Krebs S, Blum H, Moosmann A, Louissaint A Jr, Weinstock DM, Thoene S, von Bergwelt-Baildon M, Ruland J, Bararia D, Weigert O. The molecular ontogeny of follicular lymphoma: gene mutations succeeding the BCL2 translocation define common precursor cells. Br J Haematol. 2022 Mar;196(6):1381-1387. doi: 10.1111/bjh.17990. Epub 2021 Dec 29. PMID: 34967008.

Kögel A, Keidel A, Bonneau F, Schäfer IB, Conti E. The human SKI complex regulates channeling of ribosome-bound RNA to the exosome via an intrinsic gatekeeping mechanism. Mol Cell. 2022 Feb 17;82(4):756-769.e8. doi: 10.1016/j.molcel.2022.01.009. Epub 2022 Feb 3. PMID: 35120588; PMCID: PMC8860381.

Scheck MK, Lehmann L, Zaucha M, Schwarzlmueller P, Huber K, Pritsch M, Barba-Spaeth G, Thorn-Seshold O, Krug AB, Endres S, Rothenfusser S, Thorn-Seshold J. FluoRNT: A robust, efficient assay for the detection of neutralising antibodies against yellow fever virus 17D. PLoS One. 2022 Feb 9;17(2):e0262149. doi: 10.1371/journal.pone.0262149. PMID: 35139078; PMCID: PMC8827462.

Lücke AC, Vom Hemdt A, Wieseler J, Fischer C, Feldmann M, Rothenfusser S, Drexler JF, Kümmerer BM. High-Throughput Platform for Detection of Neutralizing Antibodies Using Flavivirus Reporter Replicon Particles. Viruses. 2022 Feb 8;14(2):346. doi: 10.3390/v14020346. PMID: 35215941; PMCID: PMC8880525.

Schmidt M, Kluge F, Sandmeir F, Kühn U, Schäfer P, Tüting C, Ihling C, Conti E, Wahle E. Reconstitution of 3' end processing of mammalian pre-mRNA reveals a central role of RBBP6. Genes Dev. 2022 Feb 1;36(3-4):195-209. doi: 10.1101/gad.349217.121. Epub 2022 Feb 17. PMID: 35177537; PMCID: PMC8887130.

Steiner A, Reygaerts T, Pontillo A, Ceccherini I, Moecking J, Moghaddas F, Davidson S, Caroli F, Grossi A, Castro FFM, Kalil J, Gohr FN, Schmidt FI, Bartok E, Zillinger T, Hartmann G, Geyer M, Gattorno M, Mendonça LO, Masters SL. Recessive NLRC4-Autoinflammatory Disease Reveals an Ulcerative Colitis Locus. J Clin Immunol. 2022 Feb;42(2):325-335. doi: 10.1007/s10875-021-01175-4. Epub 2021 Nov 16. PMID: 34783940; PMCID: PMC8821057

Ohto T, Tayeh AA, Nishikomori R, Abe H, Hashimoto K, Baba S, Arias-Loza AP, Soda N, Satoh S, Matsuda M, Iizuka Y, Kondo T, Koseki H, Yan N, Higuchi T, Fujita T, Kato H. Intracellular virus sensor MDA5 mutation develops autoimmune myocarditis and nephritis. J Autoimmun. 2022 Feb;127:102794. doi: 10.1016/j.jaut.2022.102794. Epub 2022 Feb 12. PMID: 35168003.

Obermann HL, Lederbogen II, Steele J, Dorna J, Sander LE, Engelhardt K, Bakowsky U, Kaufmann A, Bauer S. RNA-Cholesterol Nanoparticles Function as Potent Immune Activators via TLR7 and TLR8. Front Immunol. 2022 Jan 21;12:658895. doi: 10.3389/fimmu.2021.658895. PMID: 35126343; PMCID: PMC8814444.

Barrett B, Nguyen DH, Xu J, Guo K, Shetty S, Jones ST, Mickens KL, Shepard C, Roers A, Behrendt R, Wu L, Kim B, Santiago ML. SAMHD1 Promotes the Antiretroviral Adaptive Immune Response in Mice Exposed to Lipopolysaccharide. J Immunol. 2022 Jan 15;208(2):444-453. doi: 10.4049/jimmunol.2001389. Epub 2021 Dec 10. PMID: 34893529; PMCID: PMC8755609.

Ambike S, Cheng CC, Feuerherd M, Velkov S, Baldassi D, Afridi SQ, Porras-Gonzalez D, Wei X, Hagen P, Kneidinger N, Stoleriu MG, Grass V, Burgstaller G, Pichlmair A, Merkel OM, Ko C, Michler T. Targeting genomic SARS-CoV-2 RNA with siRNAs allows efficient inhibition of viral replication and spread. Nucleic Acids Res. 2022 Jan 11;50(1):333-349. doi: 10.1093/nar/gkab1248. PMID: 34928377; PMCID: PMC8754636.

Rosenbaum M, Schnalzger T, Engleitner T, Weiß C, Mishra R, Mibus C, Mitterer T, Rad R, Ruland J. MALT1 protease function in regulatory T cells induces MYC activity to promote mitochondrial function and cellular expansion. Eur J Immunol. 2022 Jan;52(1):85-95. doi: 10.1002/eji.202149355. Epub 2021 Nov 2. PMID: 34668583.

Albanese M, Ruhle A, Mittermaier J, Mejías-Pérez E, Gapp M, Linder A, Schmacke NA, Hofmann K, Hennrich AA, Levy DN, Humpe A, Conzelmann KK, Hornung V, Fackler OT, Keppler OT. Rapid, efficient and activation-neutral gene editing of polyclonal primary human resting CD4+ T cells allows complex functional analyses. Nat Methods. 2022 Jan;19(1):81-89. doi: 10.1038/s41592-021-01328-8. Epub 2021 Dec 23. PMID: 34949807; PMCID: PMC8748193.

Lee-Kirsch MA. Sensing of RNA stress by mTORC1 drives autoinflammation. J Clin Invest. 2022 Jan 18;132(2):e156119. doi: 10.1172/JCI156119. PMID: 35040438; PMCID: PMC8759772.

top

2021

Pennemann FL, Mussabekova A, Urban C, Stukalov A, Andersen LL, Grass V, Lavacca TM, Holze C, Oubraham L, Benamrouche Y, Girardi E, Boulos RE, Hartmann R, Superti-Furga G, Habjan M, Imler JL, Meignin C, Pichlmair A. Cross-species analysis of viral nucleic acid interacting proteins identifies TAOKs as innate immune regulators. Nat Commun. 2021 Dec 1;12(1):7009. doi: 10.1038/s41467-021-27192-w. PMID: 34853303; PMCID: PMC8636641.

Rausch L, Lutz K, Schifferer M, Winheim E, Gruber R, Oesterhaus EF, Rinke L, Hellmuth JC, Scherer C, Muenchhoff M, Mandel C, Bergwelt-Baildon M, Simons M, Straub T, Krug AB, Kranich J, Brocker T. Binding of phosphatidylserine-positive microparticles by PBMCs classifies disease severity in COVID-19 patients. J Extracell Vesicles. 2021 Dec;10(14):e12173. doi: 10.1002/jev2.12173. PMID: 34854246; PMCID: PMC8636722.

Laudenbach BT, Krey K, Emslander Q, Andersen LL, Reim A, Scaturro P, Mundigl S, Dächert C, Manske K, Moser M, Ludwig J, Wohlleber D, Kröger A, Binder M, Pichlmair A. NUDT2 initiates viral RNA degradation by removal of 5'-phosphates. Nat Commun. 2021 Nov 25;12(1):6918. doi: 10.1038/s41467-021-27239-y. PMID: 34824277; PMCID: PMC8616924.

Linke R, Limmer M, Juranek SA, Heine A, Paeschke K. The Relevance of G-Quadruplexes for DNA Repair. Int J Mol Sci. 2021 Nov 22;22(22):12599. doi: 10.3390/ijms222212599. PMID: 34830478; PMCID: PMC8620898.

Fazeli W, Bamborschke D, Moawia A, Bakhtiari S, Tafakhori A, Giersdorf M, Hahn A, Weik A, Kolzter K, Shafiee S, Jin SC, Körber F, Lee-Kirsch MA, Darvish H, Cirak S, Kruer MC, Koy A. The phenotypic spectrum of PCDH12 associated disorders - Five new cases and review of the literature. Eur J Paediatr Neurol. 2022 Jan;36:7-13. doi: 10.1016/j.ejpn.2021.10.011. Epub 2021 Oct 30. PMID: 34773825.

Langer LM, Bonneau F, Gat Y, Conti E. Cryo-EM reconstructions of inhibitor-bound SMG1 kinase reveal an autoinhibitory state dependent on SMG8. Elife. 2021 Oct 26;10:e72353. doi: 10.7554/eLife.72353. PMID: 34698635; PMCID: PMC8592573.

Al-Gburi S, Beissert S, Günther C. Molecular mechanisms of vasculopathy and coagulopathy in COVID-19. Biol Chem. 2021 Oct 19;402(12):1505-1518. doi: 10.1515/hsz-2021-0245. PMID: 34657406

Christ A, Latz E. Deciphering How NLRP3 Incites the Stromal Response in Kawasaki Vasculitis. Circ Res. 2021 Oct 15;129(9):840-842. doi: 10.1161/CIRCRESAHA.121.320131. Epub 2021 Oct 14. PMID: 34648364.

Winheim E, Rinke L, Lutz K, Reischer A, Leutbecher A, Wolfram L, Rausch L, Kranich J, Wratil PR, Huber JE, Baumjohann D, Rothenfusser S, Schubert B, Hilgendorff A, Hellmuth JC, Scherer C, Muenchhoff M, von Bergwelt-Baildon M, Stark K, Straub T, Brocker T, Keppler OT, Subklewe M, Krug AB. Impaired function and delayed regeneration of dendritic cells in COVID-19. PLoS Pathog. 2021 Oct 6;17(10):e1009742. doi: 10.1371/journal.ppat.1009742. PMID: 34614036; PMCID: PMC8523079.

Caterino M, Paeschke K. Action and function of helicases on RNA G-quadruplexes. Methods. 2021 Sep 10:S1046-2023(21)00209-7. doi: 10.1016/j.ymeth.2021.09.003. Epub ahead of print. PMID: 34509630.

Klein B, Günther C. Type I Interferon Induction in Cutaneous DNA Damage Syndromes. Front Immunol. 2021 Jul 23;12:715723. doi: 10.3389/fimmu.2021.715723. PMID: 34381458; PMCID: PMC8351592.

de Oliveira Mann CC, Hopfner KP. Nuclear cGAS: guard or prisoner? EMBO J. 2021 Aug 16;40(16):e108293. doi: 10.15252/embj.2021108293. Epub 2021 Jul 12. PMID: 34250619; PMCID: PMC8365253.

Herzner AM, Schlee M, Bartok E. The many faces of cGAS: how cGAS activation is controlled in the cytosol, the nucleus, and during mitosis. Signal Transduct Target Ther. 2021 Jul 9;6(1):260. doi: 10.1038/s41392-021-00684-3. PMID: 34244470.

de Oliveira Mann CC, Hornung V. Molecular mechanisms of nonself nucleic acid recognition by the innate immune system. Eur J Immunol. 2021 Aug;51(8):1897-1910. doi: 10.1002/eji.202049116. Epub 2021 Jul 5. PMID: 34138462.

Hepowit NL, Kolbe CC, Zelle SR, Latz E, MacGurn JA. Regulation of ubiquitin and ubiquitin-like modifiers by phosphorylation. FEBS J. 2021 Jul 2. doi: 10.1111/febs.16101. Epub ahead of print. PMID: 34214249.

Renn M, Bartok E, Zillinger T, Hartmann G, Behrendt R. Animal models of SARS-CoV-2 and COVID-19 for the development of prophylactic and therapeutic interventions. Pharmacol Ther. 2021 Jun 23;228:107931. doi: 10.1016/j.pharmthera.2021.107931. Epub ahead of print. PMID: 34171328; PMCID: PMC8219947

Meinhardt A, Ramos PC, Dohmen RJ, Lucas N, Lee-Kirsch MA, Becker B, de Laffolie J, Cunha T, Niehues T, Salzer U, Yoshimi A, Erlacher M, Peters AMJ, Ehl S, Strahm B, Speckmann C. Curative Treatment of POMP-Related Autoinflammation and Immune Dysregulation (PRAID) by Hematopoietic Stem Cell Transplantation. J Clin Immunol. 2021 Oct;41(7):1664-1667. doi: 10.1007/s10875-021-01067-7. Epub 2021 Jun 16. PMID: 34131834.

Elbracht M, Meyer R, Kricheldorf K, Gezer D, Thomas E, Betz B, Kurth I, Teichmann LL, Brümmendorf TH, Germing U, Isfort S, Koschmieder S. Germline variants in DNA repair genes, including BRCA1/2, may cause familial myeloproliferative neoplasms. Blood Adv. 2021 Sep 14;5(17):3373-3376. doi: 10.1182/bloodadvances.2021004811. PMID: 34477817.

Brägelmann J, Lorenz C, Borchmann S, Nishii K, Wegner J, Meder L, Ostendorp J, Ast DF, Heimsoeth A, Nakasuka T, Hirabae A, Okawa S, Dammert MA, Plenker D, Klein S, Lohneis P, Gu J, Godfrey LK, Forster J, Trajkovic-Arsic M, Zillinger T, Haarmann M, Quaas A, Lennartz S, Schmiel M, D'Rozario J, Thomas ES, Li H, Schmitt CA, George J, Thomas RK, von Karstedt S, Hartmann G, Büttner R, Ullrich RT, Siveke JT, Ohashi K, Schlee M, Sos ML. MAPK-pathway inhibition mediates inflammatory reprogramming and sensitizes tumors to targeted activation of innate immunity sensor RIG-I. Nat Commun. 2021 Sep 17;12(1):5505. doi: 10.1038/s41467-021-25728-8. PMID: 34535668.

Holleufer A, Winther KG, Gad HH, Ai X, Chen Y, Li L, Wei Z, Deng H, Liu J, Frederiksen NA, Simonsen B, Andersen LL, Kleigrewe K, Dalskov L, Pichlmair A, Cai H, Imler JL, Hartmann R. Two cGAS-like receptors induce antiviral immunity in Drosophila. Nature. 2021 Sep;597(7874):114-118. doi: 10.1038/s41586-021-03800-z. Epub 2021 Jul 14. PMID: 34261128.

Oberhuber M, Schopf A, Hennrich AA, Santos-Mandujano R, Huhn AG, Seitz S, Riedel C, Conzelmann KK. Glycoproteins of Predicted Amphibian and Reptile Lyssaviruses Can Mediate Infection of Mammalian and Reptile Cells. Viruses. 2021 Aug 30;13(9):1726. doi: 10.3390/v13091726. PMID: 34578307; PMCID: PMC8473393.

Tzaridis T, Bachurski D, Liu S, Surmann K, Babatz F, Gesell Salazar M, Völker U, Hallek M, Herrlinger U, Vorberg I, Coch C, Reiners KS, Hartmann G. Extracellular Vesicle Separation Techniques Impact Results from Human Blood Samples: Considerations for Diagnostic Applications. Int J Mol Sci. 2021 Aug 26;22(17):9211. doi: 10.3390/ijms22179211. PMID: 34502122; PMCID: PMC8431127.

Chu CF, Sabath F, Fibi-Smetana S, Sun S, Öllinger R, Noeßner E, Chao YY, Rinke L, Winheim E, Rad R, Krug AB, Taher L, Zielinski CE. Convalescent COVID-19 Patients Without Comorbidities Display Similar Immunophenotypes Over Time Despite Divergent Disease Severities. Front Immunol. 2021 Aug 19;12:601080. doi: 10.3389/fimmu.2021.601080. PMID: 34867933; PMCID: PMC8634761.

Berndt N, Wolf C, Fischer K, Costa EC, Knuschke P, Zimmermann N, Schmidt F, Merkel M, Chara O, Lee-Kirsch MA, Günther C. Photosensitivity and cGAS-dependent type I IFN activation in lupus patients with TREX1 deficiency. J Invest Dermatol. 2021 Aug 13:S0022-202X(21)01686-9. doi: 10.1016/j.jid.2021.04.037. Epub ahead of print. PMID: 34400195.

Körholz J, Gabrielyan A, Sowerby JM, Boschann F, Chen LS, Paul D, Brandt D, Kleymann J, Kolditz M, Toepfner N, Knöfler R, Jacobsen EM, Wolf C, Conrad K, Röber N, Lee-Kirsch MA, Smith KGC, Mundlos S, Berner R, Dalpke AH, Schuetz C, Rae W. One Gene, Many Facets: Multiple Immune Pathway Dysregulation in SOCS1 Haploinsufficiency. Front Immunol. 2021 Aug 5;12:680334. doi: 10.3389/fimmu.2021.680334. PMID: 34421895; PMCID: PMC8375263.

Serrano R, Coch C, Peters C, Hartmann G, Wesch D, Kabelitz D. Monocyte-dependent co-stimulation of cytokine induction in human γδ T cells by TLR8 RNA ligands. Sci Rep. 2021 Jul 27;11(1):15231. doi: 10.1038/s41598-021-94428-6. PMID: 34315922; PMCID: PMC8316369.

Wegner J, Zillinger T, Schlee-Guimaraes TM, Bartok E, Schlee M. An epigenetic GPI anchor defect impairs TLR4 signaling in the B cell transdifferentiation model for primary human monocytes BLaER1. Sci Rep. 2021 Jul 22;11(1):14983. doi: 10.1038/s41598-021-94386-z. Erratum in: Sci Rep. 2021 Aug 30;11(1):17661. PMID: 34294787; PMCID: PMC8298422.

Bonnekoh H, Vera C, Abad-Perez A, Radetzki S, Neuenschwander M, Specker E, Mahnke NA, Frischbutter S, Latz E, Nazaré M, Kries JV, Maurer M, Scheffel J, Krause K. Topical inflammasome inhibition with disulfiram prevents irritant contact dermatitis. Clin Transl Allergy. 2021 Jul 22;11(5):e12045. doi: 10.1002/clt2.12045. PMID: 34322217; PMCID: PMC8297992.

Boehmer DFR, Formisano S, de Oliveira Mann CC, Mueller SA, Kluge M, Metzger P, Rohlfs M, Hörth C, Kocheise L, Lichtenthaler SF, Hopfner KP, Endres S, Rothenfusser S, Friedel CC, Duewell P, Schnurr M, Koenig LM. OAS1/RNase L executes RIG-I ligand-dependent tumor cell apoptosis. Sci Immunol. 2021 Jul 16;6(61):eabe2550. doi: 10.1126/sciimmunol.abe2550. PMID: 34272227.

Jütte BB, Krollmann C, Cieslak K, Koerber RM, Boor P, Graef CM, Bartok E, Wagner M, Carell T, Landsberg J, Aymans P, Wenzel J, Brossart P, Teichmann LL. Intercellular cGAMP transmission induces innate immune activation and tissue inflammation in Trex1 deficiency. iScience. 2021 Jul 9;24(8):102833. doi: 10.1016/j.isci.2021.102833. PMID: 34368651; PMCID: PMC8326191.

Krivega M, Stiefel CM, Karbassi S, Andersen LL, Chunduri NK, Donnelly N, Pichlmair A, Storchová Z. Genotoxic stress in constitutive trisomies induces autophagy and the innate immune response via the cGAS-STING pathway. Commun Biol. 2021 Jul 2;4(1):831. doi: 10.1038/s42003-021-02278-9. PMID: 34215848; PMCID: PMC8253785.

Ramirez Alvarez C, Kee C, Sharma AK, Thomas L, Schmidt FI, Stanifer ML, Boulant S, Herrmann C. The endogenous cellular protease inhibitor SPINT2 controls SARS-CoV-2 viral infection and is associated to disease severity. PLoS Pathog. 2021 Jun 28;17(6):e1009687. doi: 10.1371/journal.ppat.1009687. PMID: 34181691; PMCID: PMC8270430.

Griffante G, Gugliesi F, Pasquero S, Dell'Oste V, Biolatti M, Salinger AJ, Mondal S, Thompson PR, Weerapana E, Lebbink RJ, Soppe JA, Stamminger T, Girault V, Pichlmair A, Oroszlán G, Coen DM, De Andrea M, Landolfo S. Human cytomegalovirus-induced host protein citrullination is crucial for viral replication. Nat Commun. 2021 Jun 23;12(1):3910. doi: 10.1038/s41467-021-24178-6. PMID: 34162877; PMCID: PMC8222335.

Stadler D, Kächele M, Jones AN, Hess J, Urban C, Schneider J, Xia Y, Oswald A, Nebioglu F, Bester R, Lasitschka F, Ringelhan M, Ko C, Chou WM, Geerlof A, van de Klundert MA, Wettengel JM, Schirmacher P, Heikenwälder M, Schreiner S, Bartenschlager R, Pichlmair A, Sattler M, Unger K, Protzer U. Interferon-induced degradation of the persistent hepatitis B virus cccDNA form depends on ISG20. EMBO Rep. 2021 Jun 4;22(6):e49568. doi: 10.15252/embr.201949568. Epub 2021 May 9. PMID: 33969602; PMCID: PMC8183418.

Stukalov A, Girault V, Grass V, Karayel O, Bergant V, Urban C, Haas DA, Huang Y, Oubraham L, Wang A, Hamad MS, Piras A, Hansen FM, Tanzer MC, Paron I, Zinzula L, Engleitner T, Reinecke M, Lavacca TM, Ehmann R, Wölfel R, Jores J, Kuster B, Protzer U, Rad R, Ziebuhr J, Thiel V, Scaturro P, Mann M, Pichlmair A. Multilevel proteomics reveals host perturbations by SARS-CoV-2 and SARS-CoV. Nature. 2021 Jun;594(7862):246-252. doi: 10.1038/s41586-021-03493-4. Epub 2021 Apr 12. PMID: 33845483.

Hayn M, Hirschenberger M, Koepke L, Nchioua R, Straub JH, Klute S, Hunszinger V, Zech F, Prelli Bozzo C, Aftab W, Christensen MH, Conzelmann C, Müller JA, Srinivasachar Badarinarayan S, Stürzel CM, Forne I, Stenger S, Conzelmann KK, Münch J, Schmidt FI, Sauter D, Imhof A, Kirchhoff F, Sparrer KMJ. Systematic functional analysis of SARS-CoV-2 proteins uncovers viral innate immune antagonists and remaining vulnerabilities. Cell Rep. 2021 May 18;35(7):109126. doi: 10.1016/j.celrep.2021.109126. Epub 2021 Apr 27. PMID: 33974846; PMCID: PMC8078906.

Linder A, Bothe V, Linder N, Schwarzlmueller P, Dahlström F, Bartenhagen C, Dugas M, Pandey D, Thorn-Seshold J, Boehmer DFR, Koenig LM, Kobold S, Schnurr M, Raedler J, Spielmann G, Karimzadeh H, Schmidt A, Endres S, Rothenfusser S. Defective Interfering Genomes and the Full-Length Viral Genome Trigger RIG-I After Infection With Vesicular Stomatitis Virus in a Replication Dependent Manner. Front Immunol. 2021 Apr 30;12:595390. doi: 10.3389/fimmu.2021.595390. PMID: 33995343; PMCID: PMC8119886.

Lainšček D, Fink T, Forstnerič V, Hafner-Bratkovič I, Orehek S, Strmšek Ž, Manček-Keber M, Pečan P, Esih H, Malenšek Š, Aupič J, Dekleva P, Plaper T, Vidmar S, Kadunc L, Benčina M, Omersa N, Anderluh G, Pojer F, Lau K, Hacker D, Correia BE, Peterhoff D, Wagner R, Bergant V, Herrmann A, Pichlmair A, Jerala R. A Nanoscaffolded Spike-RBD Vaccine Provides Protection against SARS-CoV-2 with Minimal Anti-Scaffold Response. Vaccines (Basel). 2021 Apr 27;9(5):431. doi: 10.3390/vaccines9050431. PMID: 33925446; PMCID: PMC8146944.

Hennrich AA, Sawatsky B, Santos-Mandujano R, Banda DH, Oberhuber M, Schopf A, Pfaffinger V, Wittwer K, Riedel C, Pfaller CK, Conzelmann KK. Safe and effective two-in-one replicon-and-VLP minispike vaccine for COVID-19: Protection of mice after a single immunization. PLoS Pathog. 2021 Apr 21;17(4):e1009064. doi: 10.1371/journal.ppat.1009064. PMID: 33882114; PMCID: PMC8092985.

Prabakaran T, Troldborg A, Kumpunya S, Alee I, Marinković E, Windross SJ, Nandakumar R, Narita R, Zhang BC, Carstensen M, Vejvisithsakul P, Marqvorsen MHS, Iversen MB, Holm CK, Østergaard LJ, Pedersen FS, Pisitkun T, Behrendt R, Pisitkun P, Paludan SR. A STING antagonist modulating the interaction with STIM1 blocks ER-to-Golgi trafficking and inhibits lupus pathology. EBioMedicine. 2021 Apr 1;66:103314. doi: 10.1016/j.ebiom.2021.103314. Epub ahead of print. PMID: 33813142.

Onizawa H, Kato H, Kimura H, Kudo T, Soda N, Shimizu S, Funabiki M, Yagi Y, Nakamoto Y, Priller J, Nishikomori R, Heike T, Yan N, Tsujimura T, Mimori T, Fujita T. Aicardi-Goutières syndrome-like encephalitis in mutant mice with constitutively active MDA5. Int Immunol. 2021 Mar 31;33(4):225-240. doi: 10.1093/intimm/dxaa073. PMID: 33165593.

Apel F, Andreeva L, Knackstedt LS, Streeck R, Frese CK, Goosmann C, Hopfner KP, Zychlinsky A. The cytosolic DNA sensor cGAS recognizes neutrophil extracellular traps. Sci Signal. 2021 Mar 9;14(673):eaax7942. doi: 10.1126/scisignal.aax7942. PMID: 33688080.

Karliuk Y, Vom Hemdt A, Wieseler J, Pfeffer M, Kümmerer BM. Characterization and Vector Competence Studies of Chikungunya Virus Lacking Repetitive Motifs in the 3' Untranslated Region of the Genome. Viruses. 2021 Mar 4;13(3):403. doi: 10.3390/v13030403. PMID: 33806267; PMCID: PMC7999577.

Prado Acosta M, Goyette-Desjardins G, Scheffel J, Dudeck A, Ruland J, Lepenies B. S-Layer From Lactobacillus brevis Modulates Antigen-Presenting Cell Functions via the Mincle-Syk-Card9 Axis. Front Immunol. 2021 Mar 1;12:602067. doi: 10.3389/fimmu.2021.602067. PMID: 33732234; PMCID: PMC7957004.

Alankus B, Ecker V, Vahl N, Braun M, Weichert W, Macher-Göppinger S, Gehring T, Neumayer T, Zenz T, Buchner M, Ruland J. Pathological RANK signaling in B cells drives autoimmunity and chronic lymphocytic leukemia. J Exp Med. 2021 Feb 1;218(2):e20200517. doi: 10.1084/jem.20200517. PMID: 33075129; PMCID: PMC7868734

Heinen A, Schnabel A, Brück N, Smitka M, Wolf C, Lucas N, Dollinger S, Hahn G, Günther C, Berner R, Lee-Kirsch MA, Schuetz C. Interferon signature guiding therapeutic decision making: ruxolitinib as first-line therapy for severe juvenile dermatomyositis? Rheumatology (Oxford). 2020 Nov 17:keaa657. doi: 10.1093/rheumatology/keaa657. Epub ahead of print. PMID: 33200187.

Bamborschke D, Kreutzer M, Koy A, Koerber F, Lucas N, Huenseler C, Herkenrath P, Lee-Kirsch MA, Cirak S. PNPT1 mutations may cause Aicardi-Goutières-Syndrome. Brain Dev. 2021 Feb;43(2):320-324. doi: 10.1016/j.braindev.2020.10.005. Epub 2020 Nov 4. PMID: 33158637.

Kosiol N, Juranek S, Brossart P, Heine A, Paeschke K. G-quadruplexes: a promising target for cancer therapy. Mol Cancer. 2021 Feb 25;20(1):40. doi: 10.1186/s12943-021-01328-4. PMID: 33632214; PMCID: PMC7905668.

Günther C. Research in practice: Disturbance in intracellular nucleic acid metabolism promotes lupus erythematosus. J Dtsch Dermatol Ges. 2021 Feb;19(2):209-213. doi: 10.1111/ddg.14357. PMID: 33586881.

Günther C. Forschung in der Praxis: Störung des intrazellulären Nukleinsäuremetabolismus fördert die Entwicklung des Lupus erythematodes. J Dtsch Dermatol Ges. 2021 Feb;19(2):209-214. German. doi: 10.1111/ddg.14357_g. PMID: 33586883.

Bauernfried S, Scherr MJ, Pichlmair A, Duderstadt KE, Hornung V. Human NLRP1 is a sensor for double-stranded RNA. Science. 2021 Jan 29;371(6528):eabd0811. doi: 10.1126/science.abd0811. Epub 2020 Nov 26. PMID: 33243852.

Hofmann J, Gadjalova I, Mishra R, Ruland J, Keppler SJ. Efficient Tissue Clearing and Multi-Organ Volumetric Imaging Enable Quantitative Visualization of Sparse Immune Cell Populations During Inflammation. Front Immunol. 2021 Jan 25;11:599495. doi: 10.3389/fimmu.2020.599495. PMID: 33569052; PMCID: PMC7869862.

Koenig PA, Das H, Liu H, Kümmerer BM, Gohr FN, Jenster LM, Schiffelers LDJ, Tesfamariam YM, Uchima M, Wuerth JD, Gatterdam K, Ruetalo N, Christensen MH, Fandrey CI, Normann S, Tödtmann JMP, Pritzl S, Hanke L, Boos J, Yuan M, Zhu X, Schmid-Burgk JL, Kato H, Schindler M, Wilson IA, Geyer M, Ludwig KU, Hällberg BM, Wu NC, Schmidt FI. Structure-guided multivalent nanobodies block SARS-CoV-2 infection and suppress mutational escape. Science. 2021 Jan 12:eabe6230. doi: 10.1126/science.abe6230. Epub ahead of print. PMID: 33436526.

Alon R, Sportiello M, Kozlovski S, Kumar A, Reilly EC, Zarbock A, Garbi N, Topham DJ. Leukocyte trafficking to the lungs and beyond: lessons from influenza for COVID-19. Nat Rev Immunol. 2021 Jan;21(1):49-64. doi: 10.1038/s41577-020-00470-2. Epub 2020 Nov 19. PMID: 33214719; PMCID: PMC7675406.

Schraml BU, Krug AB. Editorial for Molecular Immunology - Special issue "Novel concepts in dendritic cell development". Mol Immunol. 2021 Jan;129:112-113. doi: 10.1016/j.molimm.2020.12.001. Epub 2020 Dec 9. PMID: 33308901.

top

2020

Aschoff R, Zimmermann N, Beissert S, Günther C. Type I Interferon Signature in Chilblain-Like Lesions Associated with the COVID-19 Pandemic. Dermatopathology (Basel). 2020 Dec 4;7(3):57-63. doi: 10.3390/dermatopathology7030010. PMID: 33291622; PMCID: PMC7768511.

Szurgot I, Ljungberg K, Kümmerer BM, Liljeström P. . Infectious RNA vaccine protects mice against chikungunya virus infection. Sci Rep. 2020 Dec 3;10(1):21076. doi: 10.1038/s41598-020-78009-7. PMID: 33273501; PMCID: PMC7712826.

Schuller SK, Schuller JM, Prabu JR, Baumgärtner M, Bonneau F, Basquin J, Conti E. Structural insights into the nucleic acid remodeling mechanisms of the yeast THO-Sub2 complex. Elife. 2020 Nov 16;9:e61467. doi: 10.7554/eLife.61467. PMID: 33191913; PMCID: PMC7744097.

Michalski S, de Oliveira Mann CC, Stafford CA, Witte G, Bartho J, Lammens K, Hornung V, Hopfner KP. Structural basis for sequestration and autoinhibition of cGAS by chromatin. Nature. 2020 Nov;587(7835):678-682. doi: 10.1038/s41586-020-2748-0. Epub 2020 Sep 10. PMID: 32911480.

Abu Tayeh A, Funabiki M, Shimizu S, Satoh S, Sumin L, Iwakura Y, Kato H, Fujita T. Psoriasis-like skin disorder in transgenic mice expressing a RIG-I Singleton-Merten syndrome variant. Int Immunol. 2020 Oct 29:dxaa071. doi: 10.1093/intimm/dxaa071. Epub ahead of print. PMID: 33119735.

Krey K, Babnis AW, Pichlmair A. System-Based Approaches to Delineate the Antiviral Innate Immune Landscape. Viruses. 2020 Oct 21;12(10):1196. doi: 10.3390/v12101196. PMID: 33096788; PMCID: PMC7589202.

Schult P, Paeschke K. The DEAH helicase DHX36 and its role in G-quadruplex-dependent processes. Biol Chem. 2020 Oct 1:/j/bchm.just-accepted/hsz-2020-0292/hsz-2020-0292.xml. doi: 10.1515/hsz-2020-0292. Epub ahead of print. PMID: 33021960.

Jung S, von Thülen T, Yang I, Laukemper V, Rupf B, Janga H, Panagiotidis GD, Schoen A, Nicolai M, Schulte LN, Obermann HL, Weber F, Kaufmann A, Bauer S. A ribosomal RNA fragment with 2',3'-cyclic phosphate and GTP-binding activity acts as RIG-I ligand. Nucleic Acids Res. 2020 Sep 18:gkaa739. doi: 10.1093/nar/gkaa739. Epub ahead of print. PMID: 32946572.

Riedel C, Hennrich AA, Conzelmann KK. Components and Architecture of the Rhabdovirus Ribonucleoprotein Complex. Viruses. 2020 Aug 29;12(9):959. doi: 10.3390/v12090959. PMID: 32872471; PMCID: PMC7552012.

Sato R, Reuter T, Hiranuma R, Shibata T, Fukui R, Motoi Y, Murakami Y, Tsukamoto H, Yamazaki S, Liu K, Saitoh SI, Latz E, Miyake K. The impact of cell maturation and tissue microenvironments on the expression of endosomal Toll-like receptors in monocytes and macrophages. Int Immunol. 2020 Aug 25:dxaa055. doi: 10.1093/intimm/dxaa055. Epub ahead of print. PMID: 32840578.

Linder A, Bauernfried S, Cheng Y, Albanese M, Jung C, Keppler OT, Hornung V. CARD8 inflammasome activation triggers pyroptosis in human T cells. EMBO J. 2020 Aug 25:e105071. doi: 10.15252/embj.2020105071. Epub ahead of print. PMID: 32840892.

Lauterbach MA, Latz E, Christ A. Metabolomic Profiling Reveals Distinct and Mutual Effects of Diet and Inflammation in Shaping Systemic Metabolism in Ldlr-/- Mice. Metabolites. 2020 Aug 19;10(9):336. doi: 10.3390/metabo10090336. PMID: 32824900; PMCID: PMC7570335.

Wuerth JD, Habjan M, Kainulainen M, Berisha B, Bertheloot D, Superti-Furga G, Pichlmair A, Weber F. eIF2B as a Target for Viral Evasion of PKR-Mediated Translation Inhibition. mBio. 2020 Jul 14;11(4):e00976-20. doi: 10.1128/mBio.00976-20. PMID: 32665273; PMCID: PMC7360930

Bartok E, Hartmann G. Immune Sensing Mechanisms that Discriminate Self from Altered Self and Foreign Nucleic Acids. Immunity. 2020 Jul 14;53(1):54-77. doi: 10.1016/j.immuni.2020.06.014. PMID: 32668228; PMCID: PMC7359798.

Lucas N, Dückers G, Speckmann C, Ehl S, Utz N, Cheng B, Fang M, Niehues T, Lee-Kirsch MA. NAXD Deficiency Associated with Perinatal Autoinflammation, Pancytopenia, Dermatitis, Colitis, and Cystic Encephalomalacia. J Pediatric Neurol. July 2020, DOI: 10.1055/s-0040-1713682

Schmidt FI, Latz E. Jack of all trades inhibits inflammation (in sober people). Nat Immunol. 2020 Jul;21(7):718-719. doi: 10.1038/s41590-020-0693-6. PMID: 32577009.

Bennion BG, Croft CA, Ai TL, Qian W, Menos AM, Miner CA, Frémond ML, Doisne JM, Andhey PS, Platt DJ, Bando JK, Wang ER, Luksch H, Molina TJ, Roberson EDO, Artyomov MN, Rösen-Wolff A, Colonna M, Rieux-Laucat F, Di Santo JP, Neven B, Miner JJ. STING Gain-of-Function Disrupts Lymph Node Organogenesis and Innate Lymphoid Cell Development in Mice. Cell Rep. 2020 Jun 16;31(11):107771. doi: 10.1016/j.celrep.2020.107771. PMID: 32553167.

Lingaraju M, Schuller JM, Falk S, Gerlach P, Bonneau F, Basquin J, Benda C, Conti E. To Process or to Decay: A Mechanistic View of the Nuclear RNA Exosome. Cold Spring Harb Symp Quant Biol. 2020 Jun 3:040295. doi: 10.1101/sqb.2019.84.040295. Epub ahead of print. PMID: 32493762.

Günther C, Aschoff R, Beissert S. Cutaneous autoimmune diseases during COVID-19 pandemic. J Eur Acad Dermatol Venereol. 2020 Jun 13:10.1111/jdv.16753. doi: 10.1111/jdv.16753. Epub ahead of print. PMID: 32534461; PMCID: PMC7322985.

Langer LM, Gat Y, Bonneau F, Conti E. Structure of substrate-bound SMG1-8-9 kinase complex reveals molecular basis for phosphorylation specificity. Elife. 2020 May 29;9:e57127. doi: 10.7554/eLife.57127. Epub ahead of print. PMID: 32469312.

Siedel H, Roers A, Rösen-Wolff A, Luksch H. Type I interferon-independent T cell impairment in a Tmem173 N153S/WT mouse model of STING associated vasculopathy with onset in infancy (SAVI). Clin Immunol. 2020 May 27;216:108466. doi: 10.1016/j.clim.2020.108466. Epub ahead of print. PMID: 32470544.

Hopfner KP, Hornung V. Molecular mechanisms and cellular functions of cGAS-STING signalling. Nat Rev Mol Cell Biol. 2020 May 18. doi: 10.1038/s41580-020-0244-x. Epub ahead of print. PMID: 32424334.

Vornholz L, Ruland J. Physiological and Pathological Functions of CARD9 Signaling in the Innate Immune System. Curr Top Microbiol Immunol. 2020 May 16. doi: 10.1007/82_2020_211. Epub ahead of print. PMID: 32415389.

Huber JE, Ahlfeld J, Scheck MK, Zaucha M, Witter K, Lehmann L, Karimzadeh H, Pritsch M, Hoelscher M, von Sonnenburg F, Dick A, Barba-Spaeth G, Krug AB, Rothenfußer S, Baumjohann D. Dynamic changes in circulating T follicular helper cell composition predict neutralising antibody responses after yellow fever vaccination. Clin Transl Immunology. 2020 May 13;9(5):e1129. doi: 10.1002/cti2.1129. PMID: 32419947; PMCID: PMC7221214.

Sürün D, Schneider A, Mircetic J, Neumann K, Lansing F, Paszkowski-Rogacz M, Hänchen V, Lee-Kirsch MA, Buchholz F. Efficient Generation and Correction of Mutations in Human iPS Cells Utilizing mRNAs of CRISPR Base Editors and Prime Editors. Genes (Basel). 2020 May 6;11(5):511. doi: 10.3390/genes11050511. PMID: 32384610; PMCID: PMC7288465.

Wolf C, Brück N, Koss S, Griep C, Kirschfink M, Palm-Beden K, Fang M, Röber N, Winkler S, Berner R, Latz E, Günther C, Lee-Kirsch MA. Janus kinase inhibition in complement component 1 deficiency. J Allergy Clin Immunol. 2020 Apr 20:S0091-6749(20)30487-5. doi: 10.1016/j.jaci.2020.04.002. Epub ahead of print. PMID: 32325142.

Ostendorf T, Zillinger T, Andryka K, Schlee-Guimaraes TM, Schmitz S, Marx S, Bayrak K, Linke R, Salgert S, Wegner J, Grasser T, Bauersachs S, Soltesz L, Hübner MP, Nastaly M, Coch C, Kettwig M, Roehl I, Henneke M, Hoerauf A, Barchet W, Gärtner J, Schlee M, Hartmann G, Bartok E. Immune Sensing of Synthetic, Bacterial, and Protozoan RNA by Toll-like Receptor 8 Requires Coordinated Processing by RNase T2 and RNase 2. Immunity. 2020 Apr 14;52(4):591-605.e6. doi: 10.1016/j.immuni.2020.03.009. PMID: 32294405.

de Jesus AA, Hou Y, Brooks S, Malle L, Biancotto A, Huang Y, Calvo KR, Marrero B, Moir S, Oler AJ, Deng Z, Montealegre Sanchez GA, Ahmed A, Allenspach E, Arabshahi B, Behrens E, Benseler S, Bezrodnik L, Bout-Tabaku S, Brescia AC, Brown D, Burnham JM, Caldirola MS, Carrasco R, Chan AY, Cimaz R, Dancey P, Dare J, DeGuzman M, Dimitriades V, Ferguson I, Ferguson P, Finn L, Gattorno M, Grom AA, Hanson EP, Hashkes PJ, Hedrich CM, Herzog R, Horneff G, Jerath R, Kessler E, Kim H, Kingsbury DJ, Laxer RM, Lee PY, Lee-Kirsch MA, Lewandowski L, Li S, Lilleby V, Mammadova V, Moorthy LN, Nasrullayeva G, O'Neil KM, Onel K, Ozen S, Pan N, Pillet P, Piotto DG, Punaro MG, Reiff A, Reinhardt A, Rider LG, Rivas-Chacon R, Ronis T, Rösen-Wolff A, Roth J, Ruth NM, Rygg M, Schmeling H, Schulert G, Scott C, Seminario G, Shulman A, Sivaraman V, Son MB, Stepanovskiy Y, Stringer E, Taber S, Terreri MT, Tifft C, Torgerson T, Tosi L, Van Royen-Kerkhof A, Wampler Muskardin T, Canna SW, Goldbach-Mansky R. Distinct interferon signatures and cytokine patterns define additional systemic autoinflammatory diseases. J Clin Invest. 2020 Apr 1;130(4):1669-1682. doi: 10.1172/JCI129301. PMID: 31874111; PMCID: PMC7108905.

Ruzicka M, Koenig LM, Formisano S, Boehmer DFR, Vick B, Heuer EM, Meinl H, Kocheise L, Zeitlhöfler M, Ahlfeld J, Kobold S, Endres S, Subklewe M, Duewell P, Schnurr M, Jeremias I, Lichtenegger FS, Rothenfusser S. RIG-I-based immunotherapy enhances survival in preclinical AML models and sensitizes AML cells to checkpoint blockade. Leukemia. 2020 Apr;34(4):1017-1026. doi: 10.1038/s41375-019-0639-x. Epub 2019 Nov 18. PMID: 31740809; PMCID: PMC721425.

top

2019

Tüngler V, Doebler-Neumann M, Salandin M, Kaufmann P, Wolf C, Lucas N, Harmuth F, Reichbauer J, Krägeloh-Mann I, Schüle R, Lee-Kirsch MA. Aicardi-Goutières syndrome due to a paternal mosaic IFIH1 mutation. Neurol Genet. 2019 Dec 19;6(1):e384. doi: 10.1212/NXG.0000000000000384. PMID: 32042913; PMCID: PMC6936312.

Gat Y, Schuller JM, Lingaraju M, Weyher E, Bonneau F, Strauss M, Murray PJ, Conti E. InsP6 binding to PIKK kinases revealed by the cryo-EM structure of an SMG1-SMG8-SMG9 complex. Nat Struct Mol Biol. 2019 Dec;26(12):1089-1093. doi: 10.1038/s41594-019-0342-7. Epub 2019 Dec 2. PMID: 31792449.

Greulich W, Wagner M, Gaidt MM, Stafford C, Cheng Y, Linder A, Carell T, Hornung V. TLR8 Is a Sensor of RNase T2 Degradation Products. Cell. 2019 Nov 27;179(6):1264-1275.e13. doi: 10.1016/j.cell.2019.11.001. PMID: 31778653.

Obermann HL, Eberhardt I, Yu P, Kaufmann A, Bauer S. RNA-DNA hybrids and ssDNA differ in intracellular half-life and toll-like receptor 9 activation. Immunobiology. 2019 Nov;224(6):843-851. doi: 10.1016/j.imbio.2019.08.001. Epub 2019 Aug 10. PMID: 31521407.

Scaturro P, Kastner AL, Pichlmair A. Chasing Intracellular Zika Virus Using Proteomics. Viruses. 2019 Sep 19;11(9):878. doi: 10.3390/v11090878. PMID: 31546825; PMCID: PMC6783930.

Ruland J. Colon Cancer: Epithelial Notch Signaling Recruits Neutrophils to Drive Metastasis. Cancer Cell. 2019 Sep 16;36(3):213-214. doi: 10.1016/j.ccell.2019.08.010. PMID: 31526756.

Li K, Neumann K, Duhan V, Namineni S, Hansen AL, Wartewig T, Kurgyis Z, Holm CK, Heikenwalder M, Lang KS, Ruland J. The uric acid crystal receptor Clec12A potentiates type I interferon responses. Proc Natl Acad Sci U S A. 2019 Sep 10;116(37):18544-18549. doi: 10.1073/pnas.1821351116. Epub 2019 Aug 26. PMID: 31451663; PMCID: PMC6744871.

Soda N, Sakai N, Kato H, Takami M, Fujita T. Singleton-Merten Syndrome-like Skeletal Abnormalities in Mice with Constitutively Activated MDA5. J Immunol. 2019 Sep 1;203(5):1356-1368. doi: 10.4049/jimmunol.1900354. Epub 2019 Jul 31. PMID: 31366715.

Günther C. Nucleic Acid Immunity in the Pathogenesis of Cutaneous Lupus Erythematosus. Front Immunol. 2019 Jul 16;10:1636. doi: 10.3389/fimmu.2019.01636. PMID: 31379837; PMCID: PMC6646723.

Luksch H, Stinson WA, Platt DJ, Qian W, Kalugotla G, Miner CA, Bennion BG, Gerbaulet A, Rösen-Wolff A, Miner JJ. STING-associated lung disease in mice relies on T cells but not type I interferon. J Allergy Clin Immunol. 2019 Jul;144(1):254-266.e8. doi: 10.1016/j.jaci.2019.01.044. Epub 2019 Feb 14. PMID: 30772497; PMCID: PMC6612314.

Musumeci A, Lutz K, Winheim E, Krug AB. What Makes a pDC: Recent Advances in Understanding Plasmacytoid DC Development and Heterogeneity. Front Immunol. 2019 May 29;10:1222. doi: 10.3389/fimmu.2019.01222. PMID: 31191558; PMCID: PMC6548821.

Rosenbaum M, Gewies A, Pechloff K, Heuser C, Engleitner T, Gehring T, Hartjes L, Krebs S, Krappmann D, Kriegsmann M, Weichert W, Rad R, Kurts C, Ruland J. Bcl10-controlled Malt1 paracaspase activity is key for the immune suppressive function of regulatory T cells. Nat Commun. 2019 May 28;10(1):2352. doi: 10.1038/s41467-019-10203-2. PMID: 31138793; PMCID: PMC6538646.

Braun E, Hotter D, Koepke L, Zech F, Groß R, Sparrer KMJ, Müller JA, Pfaller CK, Heusinger E, Wombacher R, Sutter K, Dittmer U, Winkler M, Simmons G, Jakobsen MR, Conzelmann KK, Pöhlmann S, Münch J, Fackler OT, Kirchhoff F, Sauter D. Guanylate-Binding Proteins 2 and 5 Exert Broad Antiviral Activity by Inhibiting Furin-Mediated Processing of Viral Envelope Proteins. Cell Rep. 2019 May 14;27(7):2092-2104.e10. doi: 10.1016/j.celrep.2019.04.063. PMID: 31091448.

Wartewig T, Ruland J. PD-1 Tumor Suppressor Signaling in T Cell Lymphomas. Trends Immunol. 2019 May;40(5):403-414. doi: 10.1016/j.it.2019.03.005. Epub 2019 Apr 9. PMID: 30979616.

Hubel P, Urban C, Bergant V, Schneider WM, Knauer B, Stukalov A, Scaturro P, Mann A, Brunotte L, Hoffmann HH, Schoggins JW, Schwemmle M, Mann M, Rice CM, Pichlmair A. A protein-interaction network of interferon-stimulated genes extends the innate immune system landscape. Nat Immunol. 2019 Apr;20(4):493-502. doi: 10.1038/s41590-019-0323-3. Epub 2019 Mar 4. PMID: 30833792.

Albers JJ, Ammon T, Gosmann D, Audehm S, Thoene S, Winter C, Secci R, Wolf A, Stelzl A, Steiger K, Ruland J, Bassermann F, Kupatt C, Anton M, Krackhardt AM. Gene editing enables T-cell engineering to redirect antigen specificity for potent tumor rejection. Life Sci Alliance. 2019 Mar 15;2(2):e201900367. doi: 10.26508/lsa.201900367. PMID: 30877233; PMCID: PMC6421629.

Hartjes L, Ruland J. CARD9 Signaling in Intestinal Immune Homeostasis and Oncogenesis. Front Immunol. 2019 Mar 11;10:419. doi: 10.3389/fimmu.2019.00419. PMID: 30906296; PMCID: PMC6418414.

Zimmermann N, Wolf C, Schwenke R, Lüth A, Schmidt F, Engel K, Lee-Kirsch MA, Günther C. Assessment of Clinical Response to Janus Kinase Inhibition in Patients With Familial Chilblain Lupus and TREX1 Mutation. JAMA Dermatol. 2019 Mar 1;155(3):342-346. doi: 10.1001/jamadermatol.2018.5077. PMID: 30673078; PMCID: PMC6440279.

Scaturro P, Pichlmair A. Oxeiptosis: a discreet way to respond to radicals. Curr Opin Immunol. 2019 Feb;56:37-43. doi: 10.1016/j.coi.2018.10.006. Epub 2018 Oct 18. PMID: 30342374.

top

2018

Wuerth JD, Habjan M, Wulle J, Superti-Furga G, Pichlmair A, Weber F. NSs Protein of Sandfly Fever Sicilian Phlebovirus Counteracts Interferon (IFN) Induction by Masking the DNA-Binding Domain of IFN Regulatory Factor 3. J Virol. 2018 Nov 12;92(23):e01202-18. doi: 10.1128/JVI.01202-18. PMID: 30232186; PMCID: PMC6232482.

Scaturro P, Stukalov A, Haas DA, Cortese M, Draganova K, Płaszczyca A, Bartenschlager R, Götz M, Pichlmair A. An orthogonal proteomic survey uncovers novel Zika virus host factors. Nature. 2018 Sep;561(7722):253-257. doi: 10.1038/s41586-018-0484-5. Epub 2018 Sep 3. PMID: 30177828.

Lässig C, Lammens K, Gorenflos López JL, Michalski S, Fettscher O, Hopfner KP. Unified mechanisms for self-RNA recognition by RIG-I Singleton-Merten syndrome variants. Elife. 2018 Jul 26;7:e38958. doi: 10.7554/eLife.38958. PMID: 30047865; PMCID: PMC6086658.

Pelka K, Bertheloot D, Reimer E, Phulphagar K, Schmidt SV, Christ A, Stahl R, Watson N, Miyake K, Hacohen N, Haas A, Brinkmann MM, Marshak-Rothstein A, Meissner F, Latz E. The Chaperone UNC93B1 Regulates Toll-like Receptor Stability Independently of Endosomal TLR Transport. Immunity. 2018 May 15;48(5):911-922.e7. doi: 10.1016/j.immuni.2018.04.011. PMID: 29768176; PMCID: PMC6482051.

 

top