Nucleic Acid Immunity - RESEARCH PROGRAM 2023-2026
A01 - Meissner/Schmidt
Systematic dissection of cytosolic DNA sensing and signalling with nanobodies and proteomics
A02 - Bauer/Zillinger
Role of self RNA in immune sensing and tolerance
A04 - Hartmann/Kümmerer
Dissecting immune sensing of viral RNA at the insect-vertebrate barrier to guide improved messenger RNA vaccine design
A05 - Hopfner
Structural mechanisms of self-nucleic acid sensing by cGAS
A06 - Bartok/Wolf
Effects of pyroptosis on nucleic acid metabolism and immune sensing
A07 - Pichlmair
Functions and degradation of endogenously generated viral RNA
A10 - Ruland
Crosstalk of CARD9/BCL10 and STING Signalling in Nucleic Acid Immunity
A11 - Latz/Lee-Kirsch
Role of UNC93B1 in nucleic acid-sensing TLR function - relevance for the pathogenesis of systemic lupus erythematosus
B14 - Krug/Rothenfußer
Defining predictors of anti-viral immunity in the yellow fever vaccination model using gene polymorphisms and early innate response patterns
B15 - Abdullah/Kurts
Sensing of nucleic acids in the pathophysiology of glomerulonephritis associated with chronic viral infection
B16 - Garbi
Sex hormones in STING-mediated nucleic acid recognition
B17 - Roers
Molecular and cellular dynamics of nucleic acid-driven immune responses and immunopathology
B18 - Rösen-Wolff/Teichmann
Molecular and cellular dynamics of nucleic acid-driven immune responses and immunopathology
B19 - Behrendt
Mobile genetic elements as sources of endogenous immune-stimulatory nucleic acids
B20 - Günther
Intracellular nucleic acid sensing as a trigger of type I interferon-driven autoimmunity affecting the skin
B21 - Klughammer/Lee-Kirsch
Phenotypic, genetic, and transcriptional dissection of type I interferonopathies – a systems approach
B22 - Kato
Potential treatments for autoimmune disorders in a RIG-I mutant mouse model
A23 - Paeschke
Recognition and consequences of RNA G4 structures during stress and infection
A25 - de Oliveira Mann
Structural mechanism of OAS1 activation by RNA modifications across species
A26 - Alberti
Biomolecular condensates as sensors of nucleic acids
A27 - Carell/Hornung
Chemical biology of intracellular nucleic acid recognition
A28 - König
Cell-fate decision upon RNA sensing by RIG-like-I receptors and viral restriction factors
B29 - Kim-Hellmuth
Deciphering genetic regulatory effects of nucleic acid immunity in human dendritic cell populations
A30 - Geyer/Schlee
Higher-order structures of ligand-bound RIG-I and cGAS