TRR 237 Nucleic Acid Immunity
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Research Program

The research program is divided into two main research areas. Area A investigates the mechanisms of nucleic acid immunity on the molecular and cellular level, whereas area B focuses on the functional consequences of nucleic acid immunity on a systemic level. Within each area, the projects are subdivided into specific research topics:

Area A, Mechanisms of nucleic acid immunity on the molecular and cellular level:

  • Recognition of nucleic acids (A01, A02, A04, A05, A23, A25, A27, A30)
  • Regulation of nucleic acid recognition by nucleases and metabolism (A06, A07, A28)
  • Role of downstream signalling pathways and their regulation (A10, A11, A26)

Area B, Functional consequences of nucleic acid immunity on a systemic level:

  • Nucleic Acid Immunity in infection and vaccination (B14, B15, B29)
  • Nucleic Acid Immunity in sterile inflammatory diseases (B16, B17, B18, B19, B20, B21, B22)

In addition, our CRC benefits from two central projects, namely a central administrative project (Z) and a central infrastructure project (INF), which play a vital role in supporting our researchers. These structures facilitate scientific and administrative coordination, provide collaborative infrastructure and assist with -omics data analysis, ultimately helping to drive the success of our research projects.