A23 - Recognition and consequences of RNA G4 structures during stress and infection
G-quadruplex structures (G4s) are non-canonical nucleic acid structures. They can form within both RNA and DNA of host cells but are also found in all tested viral genomes. The helicase DHX36 unfolds G4s efficiently and modulates RNA stability, which directly impacts cellular stress signals. Combining molecular, immunological and next generation sequencing approaches we will reveal how and why DHX36 controls RNA G4 formation in the cytoplasm and how this relates to changes of the immune response during viral infection.
Prof. Dr. Katrin PaeschkeUniversity Hospital Bonn, Universität Bonn +49 (0)228 287-51706 External web links: |
