B22 - Potential treatments for autoimmune disorders in a RIG-I mutant mouse model
Gain-of-function mutations in the viral sensor RIG-I are known to cause the autoimmune disease Singleton Merten syndrome (SMS), an autosomal-dominant multi-system disorder characterized by dental dysplasia, aortic calcification, skeletal abnormalities, glaucoma and psoriasis. However, the mechanisms by which constitutively active RIG-I causes the pathogenesis remain unclear and effective treatments for these autoimmune disorders are missing. We have established a mouse model expressing RIG-I SMS mutant with spontaneous SMS-like pathologies. We aim to reveal the pathophysiology of each of these clinical manifestations and develop treatments for patients by analysing this mouse model.
Prof. Dr. Hiroki KatoInstitute of Cardiovascular Immunology, University Hospital Bonn +49 (0)228 287-51425 External web links: |
