B21 - Phenotypic, genetic, and transcriptional dissection of type I interferonopathies – a systems approach
Using a systems immunology approach, we propose to dissect molecular mechanisms driving alterations in cell-type composition and dysregulation of transcriptional networks in peripheral blood mononuclear cells of patients with early-onset type I IFN-driven autoinflammation and autoimmunity at the single-cell level. The expected results will provide novel insight into disease mechanisms and will pinpoint pathways and molecules that can be exploited for the development of improved diagnosis and targeted therapeutic strategies.
Prof. Dr. Min Ae Lee-Kirsch Speaker for Dresden External web links: |
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